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ea0029oc17.2 | Diabetes Basic | ICEECE2012

Placental restriction co-ordinately alters hepatic expression of microRNAs and targets related to non alcoholic fatty liver disease, in adult male sheep

Harryanto H. , De Blasio M. , Grant P. , Gatford K. , Owens J.

Placental restriction (PR) of fetal growth impairs insulin action and metabolic control in postnatal life. MicroRNAs (miRNAs) are important post-transcriptional regulators, down regulating mRNA abundance or translation. We therefore determined if PR in the sheep alters miR expression in liver, skeletal muscle and adipose tissue of adult offspring and if this associates with altered abundance of their predicted molecular targets.PR was induced by pre-preg...

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ea0044p249 | Thyroid | SFEBES2016

ESR2 mutations in RET mutation-negative familial medullary thyroid carcinoma

Afghan Wazir K. , Iacovazzo Donato , Alevizaki Maria , Foulkes William , Lugli Francesca , Druce Maralyn , Dutta Pinaki , Dang Mary N. , Gabrovska Plamena , Morrison Patrick J. , Owens Martina , Ellard Sian , Sampson Julian , De Marinis Laura , Korbonits Marta

Introduction: Approximately 25% of medullary thyroid cancer (MTC) cases arise in a familial setting, either as MEN2 or fMTC. While most of these are caused by mutations in the RET gene, a few families have unidentified mutations. Recently, a frameshift mutation in the ESR2 gene (coding oestrogen receptor beta) was found in a family with RET-negative fMTC associated with C-cell hyperplasia. In vitro, transfection of mutant ESR2 led t...

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Endocrine Abstracts

Placental restriction and fetal endocrinology during growth retardation

Placental restriction co-ordinately alters hepatic expression of microRNAs and targets related to non alcoholic fatty liver disease, in adult male sheep

ESR2 mutations in RET mutation-negative familial medullary thyroid carcinoma

BiosciAbstracts